Planarian Regeneration and Homeostasis 2 - Catenin Defines Head Versus Tail Identity During
نویسنده
چکیده
http://www.sciencemag.org/cgi/content/full/319/5861/323 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1150029/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/319/5861/323#related-content http://www.sciencemag.org/cgi/content/full/319/5861/323#otherarticles , 9 of which can be accessed for free: cites 25 articles This article 5 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/319/5861/323#otherarticles 1 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/development Development : subject collections This article appears in the following
منابع مشابه
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis.
After amputation, freshwater planarians properly regenerate a head or tail from the resulting anterior or posterior wound. The mechanisms that differentiate anterior from posterior and direct the replacement of the appropriate missing body parts are unknown. We found that in the planarian Schmidtea mediterranea, RNA interference (RNAi) of beta-catenin or dishevelled causes the inappropriate reg...
متن کامل"?-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis" (2007), by Kyle A. Gurley, Jochen C. Rink, and Alejandro Sánchez Alvarado
Alejandro Sánchez Alvarado?s laboratory group has employed molecular tools to investigate old questions about regeneration and as a result have identified some of the molecular mechanisms determining polarity [4]. Recent work by his group has shown Wnt-?-catenin signaling determines whether a tail or a head will form during regeneration in planarians. This study was motivated by work Thomas Hun...
متن کاملteashirt is required for head-versus-tail regeneration polarity in planarians.
Regeneration requires that the identities of new cells are properly specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc-finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals ...
متن کاملLocalization of planarian β-CATENIN-1 reveals multiple roles during anterior-posterior regeneration and organogenesis.
The β-catenin-dependent Wnt pathway exerts multiple context-dependent roles in embryonic and adult tissues. In planarians, β-catenin-1 is thought to specify posterior identities through the generation of an anteroposterior gradient. However, the existence of such a gradient has not been directly demonstrated. Here, we use a specific polyclonal antibody to demonstrate that nuclear β-CATENIN-1 ex...
متن کاملThe TALE Class Homeobox Gene Smed-prep Defines the Anterior Compartment for Head Regeneration
Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Rece...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008